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The chicken or the egg? Does glycaemic control predict cognitive function or the other way around?
Ithamar Ganmore1,2,3, Michal Schnaider Beeri4,5
1The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.
Diabetologia
|July 14, 2018
Summary
Cognitive function in adolescence predicts type 2 diabetes risk later in life, challenging the idea that diabetes solely causes cognitive decline. Early cognitive ability influences long-term glycemic control and brain health.
Area of Science:
- Neuroscience
- Endocrinology
- Public Health
Background:
- Type 2 diabetes and cognitive dysfunction are linked, with a common assumption that diabetes causes cognitive decline.
- Preventing both type 2 diabetes and cognitive decline are major public health goals.
- Understanding the causal relationship and disease timeline is vital for effective prevention.
Purpose of the Study:
- To investigate the causality and timeline of the relationship between type 2 diabetes and cognitive function.
- To challenge the prevailing view that type 2 diabetes solely leads to cognitive impairment.
Main Methods:
- Analysis of cognitive function in early adolescence (age 11).
- Longitudinal assessment of cognitive function and HbA1c levels up to age 79.
- Examination of cognitive function at age 70 and its association with subsequent glycemic control.
Main Results:
- Early adolescent cognitive function (age 11) predicts HbA1c levels and cognitive function at age 70.
- Lower cognitive function at age 70 is linked to increased HbA1c from age 70 to 79.
- Evidence supports a reverse causality hypothesis: cognitive function may precede poor glycemic control.
Conclusions:
- Cognitive function in early life may influence the development of type 2 diabetes.
- Interventions targeting cognitive function in young adolescents could potentially prevent type 2 diabetes.
- This research suggests a bidirectional relationship between cognitive function and type 2 diabetes.
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