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Cancer stem cells in sarcomas: Getting to the stemness core
1Laboratory of Tumor Biology, Department of Experimental Biology, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czech Republic.
Biochimica Et Biophysica Acta. General Subjects
|July 14, 2018
Summary
Cancer stem cells (CSCs) drive sarcoma development. The transcription factor Sox2 is crucial for maintaining the CSC state and is a promising target for future sarcoma research.
Area of Science:
- Pediatric oncology
- Cancer stem cell biology
- Sarcoma research
Background:
- Sarcomas are the third most common childhood malignancy.
- The cancer stem cell (CSC) paradigm is critical in understanding sarcoma biology.
- CSCs in sarcomas have been a focus of intensive research.
Purpose of the Study:
- To review current knowledge on sarcoma CSCs.
- To offer new perspectives on stemness deregulation in sarcomagenesis.
Main Methods:
- Literature review of sarcoma CSC research.
- Analysis of the role of transcription factors in sarcoma development.
Main Results:
- Specific cell surface markers for sarcoma CSCs remain elusive.
- Sarcomas may originate from immature cells undergoing pathological reprogramming.
- Transcription factor Sox2 is frequently upregulated and essential for the CSC phenotype in sarcomas.
Conclusions:
- Sox2 is a key regulator of the stem-like state in sarcomas.
- Sox2 is a significant marker for identifying sarcoma CSCs.
- Sox2 expression reporters could advance sarcoma CSC studies.
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