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Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
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Septins in kidney: A territory little explored
Anita A Wasik1, Surjya N Dash1, Sanna Lehtonen1
1Department of Pathology, University of Helsinki, Helsinki, Finland.
Cytoskeleton (Hoboken, N.J.)
|July 14, 2018
Summary
Septins, cytoskeletal proteins, are crucial for cell functions. This review explores their general roles and emerging evidence of their importance in kidney development and physiology.
Area of Science:
- Cell Biology
- Biochemistry
- Physiology
Background:
- Septins are conserved GTP-binding proteins forming cytoskeletal filaments.
- Initially identified in yeast for polarity and cytokinesis, their roles have expanded.
- Mammalian septins are implicated in diverse cellular processes like vesicle trafficking and ciliogenesis.
Purpose of the Study:
- To review the general structure and functions of septins.
- To summarize the current understanding of septin presence and roles in the kidney.
Main Methods:
- Literature review of septin research.
- Synthesis of existing data on septin functions in mammalian systems.
- Focus on studies investigating septins within kidney tissues.
Main Results:
- Septins exhibit diverse functions in cell polarity, cytoskeleton organization, and trafficking.
- Evidence suggests septins are present and active in kidney tissues.
- Specific roles in kidney development and physiology are beginning to be elucidated.
Conclusions:
- Septins are versatile proteins with significant roles in cellular and organismal physiology.
- Further research is needed to fully understand the specific functions of septins in the kidney.
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