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Roles of Steroid Receptor Coactivator 3 in Host Defense Against Bacterial Pathogens

Wenbo Chen1, Pingli Mo2, Chundong Yu2

  • 1State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, China; The First Affiliated Hospital of Xiamen University, Xiamen, China.

Critical Reviews in Immunology
|July 14, 2018
PubMed

Insights

Steroid receptor coactivator 3 (SRC-3) enhances gene expression and is crucial for development and disease. This review highlights SRC-3

Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator.
  • SRC-3 interacts with nuclear receptors and transcription factors.
  • It plays roles in development, physiology, and pathology, including cancer.

Purpose of the Study:

  • To review the role of SRC-3 in host defense against bacterial infections.
  • To discuss the clinical implications of SRC-3 in infection and disease.

Main Methods:

  • Literature review of studies on SRC-3 and bacterial infections.
  • Analysis of SRC-3's function in host defense mechanisms.

Main Results:

  • SRC-3 is implicated in host defense against bacterial pathogens.
  • Evidence suggests SRC-3's involvement in peritoneal and enteric bacterial infections.

Conclusions:

  • SRC-3 plays a significant role in the immune response to bacterial infections.
  • Understanding SRC-3's function may lead to new therapeutic strategies for infectious diseases.

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