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Candida parapsilosis endocarditis in an intravenous drug abuser: an autopsy report

Manoj Gopal Madakshira1, Amanjit Bal1, ShivaPrakash2

  • 1Department of Histopathology, Post Graduate Institute of Medical Sciences & Research, [PGIMER], Sector-12, Chandigarh, 160012, India.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|July 14, 2018
PubMed

Insights

Candida parapsilosis endocarditis is rare, often linked to intravenous drug use or prosthetic valve surgery. Autopsy revealed unique findings in an opium abuser, including widespread septic emboli and organ damage.

Area of Science:

  • Infectious Diseases
  • Cardiovascular Pathology
  • Autopsy Pathology

Background:

  • Candida parapsilosis is an uncommon cause of infective endocarditis.
  • Endocarditis typically affects native valves in intravenous drug abusers or prosthetic valves post-surgery.

Observation:

  • A 35-year-old chronic opium abuser presented with neurological deficits and fever.
  • The patient was diagnosed with Candida parapsilosis native valve endocarditis.

Findings:

  • Autopsy revealed extensive septic emboli in myocardial, cerebral, splenic, and iliac vessels.
  • Additional findings included a basal ganglia infarct, focal segmental glomerulonephritis, and talc granulomatosis in the lungs and liver.

Implications:

  • This case highlights a rare presentation of C. parapsilosis endocarditis with diverse systemic complications.
  • The findings underscore the importance of considering fungal endocarditis in at-risk populations and the potential for widespread embolic events.
Keywords:
Candida parapsilosisDrug useEndocarditisTalc granulomatosis

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