Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nerve growth factor.

H Thoenen, S Korsching, R Heumann

    Ciba Foundation Symposium
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Nerve growth factor (NGF) is crucial for neuron development and function, not cell proliferation. Research has enabled its purification and characterization, revealing evolutionary conservation of its active site.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Perioperative iron deficiency anaemia.

    BJA education·2023
    Same author

    DTI of Opioid-Exposed Fetuses Using ComBat Harmonization: A Bi-Institutional Study.

    AJNR. American journal of neuroradiology·2023
    Same author

    Research disruptions and recovery.

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
    Same author

    Closure of the perineal defect after abdominoperineal excision for rectal adenocarcinoma - ACPGBI Position Statement.

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2018
    Same author

    Colorectal cancer outcomes in patients aged over 85 years.

    Annals of the Royal College of Surgeons of England·2016
    Same author

    Ras does not contribute to the facilitation of hippocampal synaptic plasticity enabled by environmental enrichment.

    Neuroscience·2015

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Biochemistry

    Background:

    • Nerve growth factor (NGF) is a key neurotrophic molecule, distinct from mitogenic growth factors.
    • Essential for the development and maintenance of specific neuronal populations in both peripheral and central nervous systems.
    • Abundant sources like the male mouse submandibular gland facilitated NGF research.

    Purpose of the Study:

    • To investigate the regulation of NGF synthesis in target tissues.
    • To elucidate the molecular mechanisms of NGF action on neurons.
    • To review the essential biological actions of NGF.

    Main Methods:

    • Purification of NGF from abundant sources.
    • Production of specific antibodies against NGF.

    Related Experiment Videos

  • Amino acid sequencing, molecular cloning, and genomic organization studies.
  • Comparative analysis of biological activities and immunological properties of NGF from different sources.

    • Main Results:

    • NGF's active center is highly conserved across evolution.
    • Immunological properties of NGF have undergone significant evolutionary changes.
    • Understanding of NGF precursor structure and genomic organization.

    Conclusions:

    • NGF is a vital neurotrophic factor with a conserved active site.
    • Further research is focused on NGF synthesis regulation and mechanisms of action.
    • NGF plays a critical role in neuronal survival and function.