Mathematical modelling of expanded bed adsorption - a perspective on in silico process design

Area of Science:

• Chemical Engineering
• Biotechnology
• Separation Processes

Background:

• Expanded bed adsorption (EBA) integrates clarification, capture, and concentration in a single step.
• Existing mathematical models for EBA do not simultaneously predict hydrodynamics, mass transfer, and fouling.
• This limitation hinders the development and optimization of EBA-based separation processes.

Purpose of the Study:

• To address the limitations of current EBA models.
• To propose a multiscale simulation approach for advancing EBA technology.
• To enable simultaneous prediction of hydrodynamics, mass transfer, and fouling in EBA systems.

Main Methods:

• Utilizing multiphase computational fluid dynamics (CFD) for fluidized bed understanding.
• Employing a cascade of multiscale simulations.
• Integrating particle, equipment, and process scale models.

Main Results:

• The proposed multiscale simulation approach can address current EBA challenges.
• This method allows for simultaneous prediction of hydrodynamics, mass transfer, and fouling.
• Optimized design and selection of equipment, materials, and process conditions are facilitated.

Conclusions:

• A multiscale simulation strategy is crucial for advancing EBA technology.
• This approach enables comprehensive understanding and optimization of EBA processes.
• Reduced risks and development times for downstream processes involving EBA are achievable.