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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
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Responsive polymer conjugates for drug delivery applications: recent advances in bioconjugation methodologies
Daniel Cristian Ferreira Soares1, Caroline Mari Ramos Oda2, Liziane Oliveira Fonseca Monteiro2
1a Universidade Federal de Itajuba, Campus Itabira , Itabira , Brazil.
Journal of Drug Targeting
|July 17, 2018
Summary
Protein-polymer conjugates are vital for drug delivery and biotechnology. Novel synthesis methods, like living radical polymerization, enable advanced, stimuli-responsive materials for next-generation therapeutics.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Protein-polymer conjugates are increasingly important in drug delivery, biotechnology, and nanotechnology.
- Numerous conjugation strategies exist, with several polymer conjugates approved or in clinical trials.
- Controlled polymerization techniques offer enhanced control over conjugate properties.
Purpose of the Study:
- To review recent advances in synthesizing protein-polymer conjugates using controlled radical polymerization.
- To highlight the development and applications of stimuli-responsive protein-polymer conjugates.
- To explore new biomedical and pharmaceutical applications of these advanced materials.
Main Methods:
- Focus on living radical polymerization (LRP) techniques for protein conjugation.
- Discuss 'grafting from' approaches for precise biomacromolecule modification.
- Review strategies for creating well-defined, stimuli-responsive conjugates.
Main Results:
- LRP enables the synthesis of well-defined protein-polymer conjugates.
- 'Grafting from' strategies allow atomic-level modification of proteins.
- Stimuli-responsive conjugates offer tunable properties for advanced applications.
Conclusions:
- Controlled radical polymerization techniques significantly advance protein-polymer conjugate synthesis.
- Stimuli-responsive conjugates represent a new generation of 'smart' therapeutic products.
- These conjugates hold great promise for novel biomedical and pharmaceutical applications.
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