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KNDy Cells Revisited.

Aleisha M Moore1, Lique M Coolen1,2, Danielle T Porter1

  • 1Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi.

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|July 17, 2018
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Summary
This summary is machine-generated.

Kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the hypothalamus regulate reproductive neuroendocrine function. This review updates evidence on their roles in GnRH pulse generation, steroid feedback, and the preovulatory surge.

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Area of Science:

  • Neuroendocrinology
  • Reproductive Biology
  • Neuroscience

Background:

  • Kisspeptin/neurokinin B/dynorphin (KNDy) cells, identified a decade ago, are crucial in the mammalian hypothalamus.
  • These neurons play a central role in reproductive neuroendocrine function, including GnRH pulse generation and steroid feedback mechanisms.

Purpose of the Study:

  • To provide an updated review of KNDy cell functions in reproductive neuroendocrine control.
  • To assess the contribution of KNDy neurons to the GnRH pulse generator and steroid feedback.
  • To examine their role in the preovulatory GnRH/LH surge and explore emerging functions.

Main Methods:

  • Mini-review synthesizing recent research findings.
  • Analysis of evidence on KNDy peptides and their postsynaptic receptors.
  • Comparative assessment across species (rodents, ruminants, primates).

Main Results:

  • KNDy neurons are integral to episodic GnRH release and the GnRH pulse generator.
  • They act as key mediators of steroid hormone negative feedback on GnRH secretion.
  • Evidence supports their involvement in the preovulatory GnRH/LH surge, with species-specific variations.

Conclusions:

  • KNDy neurons are fundamental regulators of reproductive neuroendocrine axes.
  • Further research is needed to fully elucidate their complex roles in both reproductive and nonreproductive functions.
  • Understanding KNDy neurobiology is critical for addressing reproductive health challenges.