Related Experiment Video
Updated: Feb 7, 2026

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
Capture and release of genomic DNA by PEI modified Fe3O4/Au nanoparticles
Hanwen Sun1, Xinjun Zhu2, Lianying Zhang3
1Dezhou Institute of Advanced Materials, Dezhou University, Dezhou 253023, PR China.
Abstract:
Polyethylenimine (PEI) modified Fe3O4/Au nanoparticles were synthesized in aqueous solution and characterized by photo correlation spectroscopy (PCS) and vibrating sample magnetometer (VSM). The so-obtained Fe3O4/Au-PEI nanoparticles were capable of efficient electrostatic capture of DNA. The maximum amount of genomic DNA captured on 1.0mg Fe3O4/Au-PEI nanoparticles was 90μg. The DNA release behavior was studied and the DNA recovery from Fe3O4/Au-PEI nanoparticles approached 100% under optimal conditions. DNA extraction from mammalian cells using Fe3O4/Au-PEI nanoparticles was successfully performed. Up to approximately 43.1μg of high-purity (OD260/OD280 ratio=1.81) genomic DNA was extracted from 10mg of liver tissue. The results indicated that the prepared Fe3O4/Au-PEI nanoparticles could be successfully used for DNA capture and release.
Related Concept Videos
Genomic DNA in Prokaryotes
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic DNA in Eukaryotes
Genomics
Genome Size and the Evolution of New Genes
DNA-only Transposons
The donor site from where the transposon is excised is either degraded or...
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

