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Updated: Feb 7, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
Role of mTOR in Glucose and Lipid Metabolism
Zhuo Mao1, Weizhen Zhang2,3
1Center for Diabetes, Obesity and Metabolism, Department of Physiology, Shenzhen University Health Science Center, Shenzhen 518060, China. maoz@szu.edu.cn.
Abstract:
The mammalian target of rapamycin, mTOR is the master regulator of a cell's growth and metabolic state in response to nutrients, growth factors and many extracellular cues. Its dysregulation leads to a number of metabolic pathological conditions, including obesity and type 2 diabetes. Here, we review recent findings on the role of mTOR in major metabolic organs, such as adipose tissues, liver, muscle, pancreas and brain. And their potentials as the mTOR related pharmacological targets will be also discussed.
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