Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.4K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.4K
Drug Delivery: Overview01:16

Drug Delivery: Overview

887
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
887
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.8K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.8K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.7K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.7K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

10.4K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.4K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

834
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
834

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ITCC-P4 PDX Platform Enables Preclinical Testing of Pediatric Cancers.

Cancer research·2026
Same author

Eco-friendly fruit fly control through protein-gated mesoporous silica nanoparticles.

Journal of pesticide science·2026
Same author

Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2.

Nature cancer·2026
Same author

Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based nanoprobe.

Nature aging·2026
Same author

A toolkit for generating virtual brightfield images of histological and immunohistochemical stains from multiplexed data with AI-based channel selection and image enhancement.

Frontiers in bioinformatics·2026
Same author

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome.

Nature aging·2026

Related Experiment Video

Updated: Feb 7, 2026

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry
14:01

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry

Published on: September 13, 2022

5.8K

A versatile drug delivery system targeting senescent cells.

Daniel Muñoz-Espín1,2, Miguel Rovira3,4, Irene Galiana5,6

  • 1Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain dm742@cam.ac.uk manuel.serrano@irbbarcelona.org.

EMBO Molecular Medicine
|July 18, 2018
PubMed
Summary

Researchers developed a novel drug delivery system using galacto-oligosaccharides to target senescent cells. This approach enhances drug release in senescent cells, improving treatment efficacy and reducing side effects in aging-associated diseases.

Keywords:
chemotherapyfibrosisnanomedicinepalbociclibsenescence

More Related Videos

Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants
07:00

Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants

Published on: December 1, 2010

13.2K
A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K

Related Experiment Videos

Last Updated: Feb 7, 2026

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry
14:01

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry

Published on: September 13, 2022

5.8K
Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants
07:00

Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants

Published on: December 1, 2010

13.2K
A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K

Area of Science:

  • Biomedical Engineering
  • Gerontology
  • Pharmacology

Background:

  • Senescent cells accumulate in aging-associated diseases.
  • Eliminating senescent cells is a promising therapeutic strategy.
  • Lysosomal β-galactosidase activity is a hallmark of senescent cells.

Purpose of the Study:

  • To design a drug delivery system targeting senescent cells.
  • To utilize galacto-oligosaccharides for drug encapsulation.
  • To leverage senescent cell-specific enzyme activity for drug release.

Main Methods:

  • Encapsulation of drugs with galacto-oligosaccharides.
  • In vivo studies in mouse models.
  • Evaluation of drug release, therapeutic efficacy, and side effects.

Main Results:

  • Gal-encapsulated fluorophores preferentially released in senescent cells in mice.
  • Gal-encapsulated cytotoxic drugs improved tumor xenograft regression.
  • Targeting senescent cells reduced collagen deposition and restored lung function in pulmonary fibrosis models.
  • Gal-encapsulation reduced toxic side effects of cytotoxic drugs.

Conclusions:

  • Gal-encapsulation provides a targeted drug delivery system for senescent cells.
  • This approach shows therapeutic potential for senescence-associated disorders.
  • Drug delivery into senescent cells opens new diagnostic and therapeutic avenues.