Related Experiment Video
Updated: Feb 7, 2026
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
941
CLA+ T Cell Response to Microbes in Psoriasis
Carmen De Jesús-Gil1, Ester Ruiz-Romeu1, Marta Ferran2,3
1Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
Frontiers in Immunology
|July 18, 2018
Summary
Streptococcus pyogenes infections trigger psoriasis by activating specific T cells in the skin. This research explores how these microbes and immune responses contribute to psoriasis development.
Area of Science:
- Immunology
- Dermatology
- Microbiology
Background:
- Streptococcus pyogenes infections are known triggers for psoriasis.
- Cutaneous lymphocyte-associated antigen (CLA)-positive memory T cells are key players in skin immunity and disease.
- These cells are considered biomarkers for T-cell-mediated skin conditions.
Purpose of the Study:
- To investigate the role of S. pyogenes in activating CLA+ T cells in psoriasis.
- To explore novel mechanisms in psoriasis pathogenesis, including HLA-Cw6, IL-9, and Candida albicans.
- To provide a translational perspective on microbe-induced psoriasis via CLA+ T cell responses.
Main Methods:
- Coculture of autologous epidermal cells with S. pyogenes-activated CLA+ T cells from psoriasis patients.
- Analysis of T cell activation and mediator induction ex vivo.
- Exploration of genetic (HLA-Cw6) and cytokine (IL-9) influences on immune responses.
Main Results:
- S. pyogenes selectively activates CLA+ T cells in both guttate and plaque psoriasis, inducing IL-17.
- The study examines the impact of HLA-Cw6 on T cell activation in guttate psoriasis.
- Investigated the role of IL-9 in microbe-induced IL-17 responses and novel Candida albicans functions.
Conclusions:
- S. pyogenes-driven CLA+ T cell activation is a central mechanism in psoriasis pathogenesis.
- Understanding these microbe-T cell interactions offers new therapeutic targets for psoriasis.
- This research highlights a translational approach to studying psoriasis through the lens of cutaneous immunity.
Related Concept Videos
01:22Diversity in Cell Signaling Responses
8.0K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
8.0K
01:40Cell-mediated Immune Responses
84.2K
Overview
84.2K
01:23Cells of the Adaptive Immune Response
8.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.9K
01:28Cells of the Innate Immune Response
9.3K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.3K
01:22Target Cell Response to Hormones
5.8K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
5.8K
01:13Cell-matrix's Response to Mechanical Forces
3.6K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
3.6K