Related Experiment Video
Updated: Feb 7, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Anthropometry and Malaria among Children in Niger: A Cross-Sectional Study
Kieran S O'Brien1, Abdou Amza2, Boubacar Kadri2
1Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California.
Insights
This study found no strong link between malnutrition indicators and malaria infection in young children in Niger. However, greater height may be associated with a higher risk of clinical malaria.
Area of Science:
- Global Health
- Pediatric Infectious Diseases
- Nutritional Epidemiology
Background:
- Malnutrition and malaria disproportionately affect children under 5 in sub-Saharan Africa, often co-occurring seasonally.
- Previous research on the malnutrition-malaria relationship in children has yielded inconclusive results.
- Understanding this complex interaction is crucial for public health interventions.
Purpose of the Study:
- To investigate the association between anthropometric indicators of malnutrition and malaria infection in children under 5 years old in Niger.
- To analyze the relationship between height-for-age z-score (HAZ) and weight-for-age z-score (WAZ) with malaria parasitemia and clinical malaria.
Main Methods:
- Secondary analysis of a cluster-randomized trial on trachoma treatment in Niger.
- Cross-sectional study including 1,649 children aged 6-60 months with anthropometric and malaria data.
- Statistical models evaluated associations between HAZ/WAZ and malaria parasitemia/clinical malaria.
Main Results:
- 47.3% of children had malaria parasitemia and 24.3% had clinical malaria.
- No significant association was found between height-for-age z-score (HAZ) or weight-for-age z-score (WAZ) and malaria parasitemia.
- A potential association was observed between greater height and an increased risk of clinical malaria.
Conclusions:
- Most anthropometric indicators were not significantly associated with malaria infection in this population.
- Height-for-age z-score showed a marginal association with increased risk of clinical malaria.
- Further research is needed to clarify the nuanced relationship between nutritional status and malaria risk in children.
Abstract:
The complex relationship between malnutrition and malaria affects morbidity and mortality in children younger than 5 years, particularly in parts of sub-Saharan Africa where these conditions occur together seasonally. Previous research on this relationship has been inconclusive. Here, we examine the association between anthropometric indicators and malaria infection in a population-based sample of children younger than 5 years in Niger. This cross-sectional study is a secondary analysis of a cluster-randomized trial comparing treatment strategies for trachoma in Niger. We included children aged 6-60 months residing in the 48 communities enrolled in the trial who completed anthropometric and malaria infection assessments at the final study visit. We evaluated the association between anthropometric indicators, including height-for-age z-score (HAZ) and weight-for-age z-score (WAZ) and indicators of malaria infection, including malaria parasitemia and clinical malaria. In May 2013, we collected data from 1,649 children. Of these, 780 (47.3%) were positive for malaria parasitemia and 401 (24.3%) had clinical malaria. In models of malaria parasitemia, the adjusted odds ratio (aOR) was 1.05 (95% confidence interval [CI]: 1.00-1.10) for HAZ and 1.07 (95% CI: 0.99, 1.15) for WAZ. In models of clinical malaria, the aOR was 1.07 (95% CI: 1.02-1.11) for HAZ and 1.09 (95% CI: 1.01-1.19) for WAZ. Overall, we did not find evidence of an association between most anthropometric indicators and malaria infection. Greater height may be associated with an increased risk of clinical malaria.
Related Concept Videos
Cross-Sectional Research
Finding Volume Using Cross-Sectional Area
Profile Leveling and Cross Sections
Spinal Cord: Cross-sectional Anatomy
Gray Matter and its Components
Central to the gray matter is...
Crossing Over
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
Crossing Over

