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Updated: Feb 7, 2026
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Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
Published on: March 4, 2021
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REVERSIBLE RETINAL TOXICITY IN A PATIENT TAKING AXITINIB
Thomas L Jenkins1, Christopher M Aderman, Allen C Ho
1Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Philadelphia, Pennsylvania.
Retinal Cases & Brief Reports
|July 18, 2018
Summary
Axitinib, a kinase inhibitor for advanced renal cell carcinoma, may cause retinal toxicity. This case report details vision changes and retinal findings in a patient treated with axitinib.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Axitinib is a targeted therapy for advanced renal cell carcinoma (RCC).
- Understanding potential side effects is crucial for patient management.
Observation:
- A patient with metastatic RCC developed blurred vision, floaters, and photopsias.
- These symptoms emerged after initiating higher-dose axitinib therapy.
Findings:
- Funduscopic examination revealed bilateral retinal hemorrhages and cotton wool spots.
- These ocular findings demonstrated improvement upon discontinuation of axitinib.
Implications:
- Axitinib may be associated with microangiopathic retinal toxicity.
- Ophthalmologic monitoring may be warranted in patients receiving axitinib.
- This case highlights a potential adverse event of axitinib therapy.
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