REVERSIBLE RETINAL TOXICITY IN A PATIENT TAKING AXITINIB

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Updated: Feb 7, 2026

Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
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Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery

Published on: March 4, 2021

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Thomas L Jenkins1, Christopher M Aderman, Allen C Ho

  • 1Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Philadelphia, Pennsylvania.

Retinal Cases & Brief Reports
|July 18, 2018
PubMed
Abstract

Insights

Axitinib, a kinase inhibitor for advanced renal cell carcinoma, may cause retinal toxicity. This case report details vision changes and retinal findings in a patient treated with axitinib.

Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Axitinib is a targeted therapy for advanced renal cell carcinoma (RCC).
  • Understanding potential side effects is crucial for patient management.

Observation:

  • A patient with metastatic RCC developed blurred vision, floaters, and photopsias.
  • These symptoms emerged after initiating higher-dose axitinib therapy.

Findings:

  • Funduscopic examination revealed bilateral retinal hemorrhages and cotton wool spots.
  • These ocular findings demonstrated improvement upon discontinuation of axitinib.

Implications:

  • Axitinib may be associated with microangiopathic retinal toxicity.
  • Ophthalmologic monitoring may be warranted in patients receiving axitinib.
  • This case highlights a potential adverse event of axitinib therapy.

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