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The Accuracy of Left Ventricular and Left Atrial Volumetry Using 64-Slice Computed Tomography: In Vitro Validation
Vesa Järvinen, Valtteri Uusitalo, Tuula Tolvanen1
1Turku PET Center, University of Turku.
Objective:
We aimed to validate the accuracy of imaging of left atrial and ventricular volumes using cardiac cadaveric silicone casts.
Methods:
Left atrial (n = 14) and ventricular (n = 15) casts were imaged using 64-slice computed tomography (CT). Water displacement (WD) of cardiac casts was used as the gold standard for volume measurements.
Results:
Compared with WD, CT resulted in slightly higher left atrial and ventricular volumes (54 ± 25 vs 56 ± 26 mL [P = 0.003] and 57 ± 47 vs 66 ± 47 mL [P = 0.0001]). Variability between left atrial and ventricular volumes by CT and WD was low (coefficients of variation [CVs], 4% [intraclass correlation coefficient {ICC}, 0.99] and 12% [ICC, 0.97]). Intraobserver variability of CT was low for both the left atrium and the left ventricle (CVs, 1% [ICC, 1.00] and 4% [ICC, 1.00]).
Conclusions:
Cardiac CT is both accurate and reproducible in assessment of left ventricular and atrial chamber volumes.
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