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Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
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Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

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Arterial spin labeling: Clinical applications.

Mai-Lan Ho1

  • 1Division of Neuroradiology, Mayo Clinic, 200 First St. SW, 55905 Rochester, MN, United States.

Journal of Neuroradiology = Journal De Neuroradiologie
|July 18, 2018
PubMed
Summary
This summary is machine-generated.

Arterial spin labeling (ASL) is a non-contrast MRI technique for measuring cerebral blood flow (CBF). Understanding ASL principles and perfusion variations is key for diagnosing various neurological disorders.

Keywords:
Arterial spin labelingCerebral blood flowPerfusionPostlabel delay

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Area of Science:

  • Radiology
  • Neuroimaging
  • Medical Physics

Background:

  • Arterial spin labeling (ASL) is an advanced magnetic resonance imaging (MRI) technique.
  • It quantifies cerebral blood flow (CBF) without requiring intravenous contrast agents like gadolinium.
  • Familiarity with ASL's technical underpinnings and physiological perfusion variations is crucial.

Purpose of the Study:

  • To highlight the importance of understanding Arterial Spin Labeling (ASL) principles.
  • To emphasize the role of ASL in identifying normal variants and artifacts in cerebral blood flow (CBF) imaging.
  • To underscore the diagnostic utility of ASL in various cerebrovascular and neurological conditions.

Main Methods:

  • ASL technique principles.
  • Analysis of physiological variations in cerebral perfusion.
  • Review of ASL applications in neurological disorders.

Main Results:

  • ASL provides contrast-agent-free CBF quantification.
  • Knowledge of ASL and perfusion variations aids in distinguishing normal findings from artifacts.
  • ASL detects perfusion abnormalities in diverse pathologies.

Conclusions:

  • ASL is a valuable tool for non-invasive CBF measurement.
  • Understanding ASL technical basis and physiologic variations is essential for accurate interpretation.
  • ASL imaging is applicable to a wide spectrum of neurological diseases including ischemia, tumors, and dementia.