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Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1

Moustafa T Gabr1, Mohammed S Abdel-Raziq2

  • 1Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt; Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.

Bioorganic & Medicinal Chemistry Letters
|July 19, 2018
PubMed

Keywords:
AcetylcholinesteraseDonepezilHybridizationMulti-target-directed ligandsβ-Secretase

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