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Sequence evolution within populations under multiple types of mutation.

G B Golding, C F Aquadro, C H Langley

    Proceedings of the National Academy of Sciences of the United States of America
    |January 1, 1986
    PubMed
    Summary
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    Neutral models struggle to explain DNA sequence changes in Drosophila melanogaster. Mildly deleterious selection, particularly for transposable elements and deletions, better accounts for observed evolutionary patterns near the Adh locus.

    Area of Science:

    • Evolutionary biology
    • Population genetics
    • Molecular evolution

    Background:

    • Phylogenetic history can be estimated using DNA sequence and restriction map data from natural populations.
    • Studying multiple mutational types allows for comparison of distinct substitutional process rates.

    Purpose of the Study:

    • To construct a neutral model for sequence haplotype frequencies based on their evolutionary origins.
    • To apply this haplotype frequency theory to the alcohol dehydrogenase (Adh) gene region in Drosophila melanogaster.
    • To investigate the role of selection in observed DNA sequence patterns.

    Main Methods:

    • Construction of a neutral model for sequence haplotype frequencies.
    • Application of the model to DNA data from the Adh gene region of Drosophila melanogaster.

    Related Experiment Videos

  • Analysis of patterns associated with transposable elements and small deletions.

    • Main Results:

    • Observed patterns of change around the Adh locus, particularly those involving transposable elements, did not align with a simple neutral model.
    • Mutation rates alone could not reconcile the data with the neutral model.
    • Incorporating mildly deleterious selection improved the model's ability to explain the observed patterns.

    Conclusions:

    • Transposable elements appear to be mildly deleterious to organisms, at levels slightly higher than their transposition rates.
    • Small deletions in the Adh region also seem to be subject to mildly deleterious selection.
    • A neutral model requires modifications, such as the inclusion of mild selection, to accurately reflect evolutionary dynamics in specific gene regions.