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Cerebellar Structural Abnormalities Associated With Cognitive Function in Patients With First-Episode Psychosis.

Taekwan Kim¹, Kwang-Hyuk Lee¹, Hyerim Oh¹

¹Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.

Frontiers in Psychiatry

|July 19, 2018

Summary

Early-stage schizophrenia patients show reduced left cerebellar lobule volumes, linked to executive function deficits. These cerebellar abnormalities correlate with cognitive impairments in first-episode psychosis.

Keywords:

FEP SUIT cerebellum executive function neurocognition neuroimaging schizophrenia

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Area of Science:

Neuroscience
Psychiatry
Neuroimaging

Background:

The cerebellum's role in cognition is increasingly recognized.
Cerebellar structural abnormalities in schizophrenia are inconsistently reported.
Understanding these abnormalities' impact on cognition is crucial.

Purpose of the Study:

To investigate cerebellar lobular volumes in first-episode psychosis (FEP).
To examine the association between cerebellar structure and cognitive/clinical features in FEP.

Main Methods:

Utilized the spatially unbiased atlas template of the cerebellum (SUIT) for detailed lobular volume analysis.
Compared cerebellar volumes in 40 FEP patients and 40 healthy controls (HCs).
Correlated cerebellar volumes with cognitive test performance (WCST, TMT-B).

Main Results:

FEP patients exhibited smaller left cerebellar lobules VI and X volumes compared to HCs.
Reduced left lobule VI and X volumes correlated with poorer performance on the Wisconsin Card Sorting Test (WCST).
Smaller left lobule X volume was associated with delayed performance on the Trail Making Test (TMT) Part B.

Conclusions:

Cerebellar structural abnormalities are present in the early stages of schizophrenia.
These structural changes are functionally associated with non-verbal executive dysfunctions in FEP.
Findings highlight the cerebellum's involvement in early psychosis and cognitive deficits.