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Cerebellar Structural Abnormalities Associated With Cognitive Function in Patients With First-Episode Psychosis
Taekwan Kim1, Kwang-Hyuk Lee1, Hyerim Oh1
1Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
Frontiers in Psychiatry
|July 19, 2018
Summary
Early-stage schizophrenia patients show reduced left cerebellar lobule volumes, linked to executive function deficits. These cerebellar abnormalities correlate with cognitive impairments in first-episode psychosis.
Area of Science:
- Neuroscience
- Psychiatry
- Neuroimaging
Background:
- The cerebellum's role in cognition is increasingly recognized.
- Cerebellar structural abnormalities in schizophrenia are inconsistently reported.
- Understanding these abnormalities' impact on cognition is crucial.
Purpose of the Study:
- To investigate cerebellar lobular volumes in first-episode psychosis (FEP).
- To examine the association between cerebellar structure and cognitive/clinical features in FEP.
Main Methods:
- Utilized the spatially unbiased atlas template of the cerebellum (SUIT) for detailed lobular volume analysis.
- Compared cerebellar volumes in 40 FEP patients and 40 healthy controls (HCs).
- Correlated cerebellar volumes with cognitive test performance (WCST, TMT-B).
Main Results:
- FEP patients exhibited smaller left cerebellar lobules VI and X volumes compared to HCs.
- Reduced left lobule VI and X volumes correlated with poorer performance on the Wisconsin Card Sorting Test (WCST).
- Smaller left lobule X volume was associated with delayed performance on the Trail Making Test (TMT) Part B.
Conclusions:
- Cerebellar structural abnormalities are present in the early stages of schizophrenia.
- These structural changes are functionally associated with non-verbal executive dysfunctions in FEP.
- Findings highlight the cerebellum's involvement in early psychosis and cognitive deficits.
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