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REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)

Po-Chi Chan1, Hsun-Hua Lee2,3,4,5, Chien-Tai Hong2,3

  • 1Department of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan.

Behavioural Neurology
|July 19, 2018
PubMed

Insights

Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder characterized by acting out dreams. It is closely linked to Dementia with Lewy bodies (DLB), potentially sharing a common cause.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Neurodegenerative Diseases

Background:

  • Rapid eye movement sleep behavior disorder (RBD) involves acting out dreams during REM sleep.
  • RBD can be idiopathic or secondary to neurological conditions or medications.
  • Dementia with Lewy bodies (DLB) is a common dementia, often presenting with rapid cognitive decline.

Purpose of the Study:

  • To review the history, clinical features, pathophysiology, and treatment of DLB and RBD.
  • To explore the established association between RBD and DLB.
  • To provide current updates on these interconnected conditions.

Main Methods:

  • Literature review of studies on RBD and DLB.
  • Analysis of clinical manifestations and diagnostic criteria.
  • Discussion of underlying pathophysiological mechanisms, including synucleinopathy.

Main Results:

  • RBD is a core feature of DLB, often preceding or coinciding with cognitive symptoms.
  • A shared underlying synucleinopathy is strongly suggested as the cause for both RBD and DLB.
  • Evidence supports a significant pathophysiological link between these two conditions.

Conclusions:

  • RBD is a key indicator for potential DLB development.
  • Understanding the shared synucleinopathy is crucial for diagnosing and managing DLB and RBD.
  • Further research into synucleinopathies may lead to novel therapeutic strategies.

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