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Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

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Outcomes of Patients With High-Risk Plaques Treated With a Bioresorbable Magnesium Scaffold: Insights From the BIOMAG-I Study.

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Related Experiment Video

Updated: Feb 7, 2026

Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis
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Early collapse causing stenosis in a resorbable magnesium scaffold.

Thomas Marynissen1, Keir McCutcheon1, Johan Bennett1

  • 1Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, 3000, Belgium.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|July 19, 2018
PubMed
Summary

Early in-stent restenosis occurred because a Magmaris resorbable magnesium scaffold collapsed. This case highlights potential complications with novel bioresorbable scaffold devices.

Keywords:
ACS/NSTEMIbioabsorbable devicespercutaneous coronary interventionpolymers

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Area of Science:

  • Cardiovascular medicine
  • Biomaterials science
  • Interventional cardiology

Background:

  • Bioresorbable scaffolds (BRS) offer potential advantages over traditional metallic stents.
  • Magnesium-based scaffolds are being investigated for their favorable degradation properties.
  • Ensuring long-term scaffold integrity and patency is crucial for successful clinical translation.

Observation:

  • A patient presented with symptoms suggestive of early in-stent restenosis.
  • Imaging revealed a significant collapse of the Magmaris resorbable magnesium scaffold.
  • The scaffold failure occurred earlier than typically expected for bioresorbable devices.

Findings:

  • The primary finding was scaffold collapse leading to in-stent restenosis.
  • This suggests a potential mechanical failure mode for this specific resorbable magnesium scaffold.
  • Histopathological analysis may be required to fully elucidate the mechanism of collapse.

Implications:

  • This case underscores the importance of mechanical stability in bioresorbable scaffold design.
  • Further research is needed to understand the long-term performance and potential failure modes of magnesium scaffolds.
  • Clinical surveillance protocols may need to consider potential scaffold-related complications.