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The Association of Thyroid Function With Bone Density During Childhood.
Karlien Veldscholte1,2,3, Mirjana Barjaktarovic1,2,3, Katerina Trajanoska1,4
1Department of Internal Medicine, Erasmus Medical Center, GE Rotterdam, Netherlands.
The Journal of Clinical Endocrinology and Metabolism
|July 19, 2018
Summary
Higher free thyroxine (FT4) levels in children are linked to lower bone mass. This study highlights the impact of thyroid function on bone development during childhood.
Area of Science:
- Pediatric Endocrinology
- Bone Biology
- Thyroid Function
Background:
- The skeleton is a known target organ for thyroid hormones.
- Limited data exist on thyroid function's impact on childhood bone health.
Purpose of the Study:
- To investigate the association between thyroid function and bone mass in children.
Main Methods:
- Prospective cohort study of 4204 children.
- Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) measured at age 6.
- Bone density assessed via dual-energy X-ray absorptiometry at ages 6 and 10.
Main Results:
- Inverse association found between TSH and bone mineral density (BMD) at ages 6 and 10.
- Higher FT4 levels correlated with lower BMD and bone mineral content (BMC) cross-sectionally and at age 10.
Conclusions:
- Elevated FT4 concentrations are associated with reduced bone mass in children.
- Findings offer insights into thyroid hormone's role in childhood bone physiology.
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