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MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma

Xuejun Gao1, Zhenyu Chen2, Aiqin Li1

  • 1Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266006, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 20, 2018
PubMed

Insights

MAL2 protein promotes papillary thyroid carcinoma (PTC) growth and spread. Targeting the miR-129-MAL2 pathway may offer a new therapeutic strategy for PTC patients.

Area of Science:

  • Molecular biology
  • Oncology
  • Cell biology

Background:

  • MAL2 is a MAL proteolipid family member crucial for raft-mediated transport.
  • Papillary thyroid carcinoma (PTC) is a common endocrine malignancy.

Purpose of the Study:

  • To investigate the role and mechanism of MAL2 in PTC development.
  • To explore the regulatory relationship between MAL2 and miR-129 in PTC.

Main Methods:

  • Analysis of MAL2 expression in human PTC tissues.
  • In vitro and in vivo experiments involving MAL2 knockdown and miR-129 manipulation.
  • Luciferase reporter assays to confirm direct binding of miR-129 to MAL2 3' UTR.

Main Results:

  • MAL2 was upregulated in PTC tissues and correlated with poor overall survival.
  • MAL2 knockdown inhibited PTC cell proliferation and invasion, and suppressed tumor growth.
  • miR-129 directly targeted MAL2, suppressing its expression and inhibiting PTC cell growth and invasion.

Conclusions:

  • MAL2 functions as an oncogene in PTC development.
  • MAL2 is negatively regulated by miR-129 in PTC.
  • The miR-129-MAL2 axis represents a potential therapeutic target for PTC.
Keywords:
InvasionMAL2MiR-129Papillary thyroid carcinoma (PTC)Tumor growth

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