Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

5.6K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.6K
Synthetic Disvision of Polynomials01:28

Synthetic Disvision of Polynomials

191
Synthetic division is an efficient algorithmic approach for dividing a polynomial by a linear binomial of the form x - c, where c is a real number. This method is helpful due to its streamlined process, which avoids the more cumbersome steps involved in the traditional long division of polynomials. It simplifies computation and serves as a practical tool for evaluating polynomials and identifying their factors.To perform synthetic division, one begins by listing the coefficients of the...
191
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.1K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.1K
Polymers02:34

Polymers

41.1K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
41.1K
Vision01:24

Vision

60.1K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
60.1K
Base Excision Repair01:54

Base Excision Repair

26.4K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Free energy simulations on a biomimetic glucose receptor: understanding the selectivity of GluHUT.

Chemical science·2026
Same author

Making molecules work - stories of supramolecular translation.

Chemical science·2025
Same author

Bicyclic anionic receptors for carboxylates in water.

Chemical science·2025
Same author

Generating Real-World Evidence From the Excellence Network in Rheumatology.

Pharmacoepidemiology and drug safety·2024
Same author

Glucose-sensitive insulin with attenuation of hypoglycaemia.

Nature·2024
Same author

Polyanionic Receptors for Carboxylates in Water.

Angewandte Chemie (International ed. in English)·2024

Related Experiment Video

Updated: Feb 7, 2026

Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons
09:25

Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons

Published on: September 15, 2011

18.6K

Maltodextrin recognition by a macrocyclic synthetic lectin.

Patrick Stewart1, Charles M Renney1, Tiddo J Mooibroek2

  • 1School of Chemistry of the University of Bristol Cantock's Close, BS8 1TS, Bristol, UK. Anthony.Davis@bristol.ac.uk.

Chemical Communications (Cambridge, England)
|July 20, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a novel synthetic lectin with enhanced carbohydrate binding in water. Methoxy groups on the lectin favor specific α-linked maltodextrins over other substrates.

More Related Videos

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples
20:23

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

Published on: October 1, 2009

16.5K
Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

8.2K

Related Experiment Videos

Last Updated: Feb 7, 2026

Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons
09:25

Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons

Published on: September 15, 2011

18.6K
A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples
20:23

A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

Published on: October 1, 2009

16.5K
Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

8.2K

Area of Science:

  • Carbohydrate chemistry
  • Supramolecular chemistry
  • Synthetic biology

Background:

  • Lectins are proteins that bind carbohydrates, playing roles in biological recognition.
  • Synthetic lectins offer tunable properties for applications in diagnostics and therapeutics.
  • Aromatic surfaces and specific substituents can modulate lectin-carbohydrate interactions.

Purpose of the Study:

  • To design and synthesize a monocyclic "temple" synthetic lectin with extended electron-rich aromatic surfaces.
  • To investigate the binding affinities of this synthetic lectin for various carbohydrates in aqueous media.
  • To explore the influence of methoxy substituents on carbohydrate binding specificity.

Main Methods:

  • Synthesis of a monocyclic "temple" structure with electron-rich aromatic surfaces.
  • Incorporation of methoxy substituents onto the aromatic surfaces.
  • Carbohydrate binding assays in aqueous solution to determine affinities.
  • Comparative analysis of binding to different carbohydrate structures, including α-linked maltodextrins.

Main Results:

  • The synthetic lectin demonstrated enhanced binding affinities for carbohydrates in water.
  • Methoxy substituents were found to favor binding to α-linked maltodextrins.
  • This preference contrasts with the typical binding of similar receptors to all-equatorial substrates.
  • The extended electron-rich aromatic surfaces contribute to the observed binding enhancement.

Conclusions:

  • A novel synthetic lectin with tunable carbohydrate recognition properties has been developed.
  • The specific design, including methoxy substituents, enables selective binding to α-linked maltodextrins in water.
  • This work provides insights into the rational design of synthetic receptors for targeted carbohydrate recognition.