Related Experiment Video
Updated: Feb 7, 2026

Performing Intracochlear Electrocochleography During Cochlear Implantation
Published on: March 8, 2022
Predicting sequential bilateral cochlear implantation performance in postlingually deafened adults; A retrospective
Yvette E Smulders1,2,3,4, Thomas Hendriks2,3, Inge Stegeman5
1Ear Science Institute Australia, Subiaco, Western Australia, Australia.
Successful sequential bilateral cochlear implantation (CI2) depends on preoperative hearing aid use and first cochlear implant (CI1) performance. Patients with better hearing aid use, lower pure-tone average, and higher CI1 scores achieve better CI2 outcomes.
Area of Science:
- Audiology
- Otolaryngology
- Biomedical Engineering
Background:
- Sequential bilateral cochlear implantation (CI) is a common procedure for profound hearing loss.
- Predicting outcomes for the second cochlear implant (CI2) is crucial for patient counseling and management.
- Preoperative patient characteristics may significantly influence CI2 performance.
Purpose of the Study:
- To identify preoperative factors affecting speech understanding after sequential bilateral cochlear implantation.
- To develop a statistical model for predicting the benefit of CI2.
Main Methods:
- A multicentre retrospective cohort study included 92 adult patients with postlingual deafness undergoing sequential cochlear implantation.
- Speech understanding was assessed using the Consonant-Nucleus-Consonant (CNC) phoneme score at 12 months post-CI2.
- Statistical analysis explored the correlation between 18 preoperative factors and CI2 speech performance.
Main Results:
- Hearing aid use before CI2 (r = 0.46) and higher first CI (CI1) CNC scores (r = 0.21) positively correlated with CI2 outcomes.
- Longer duration of hearing loss before CI2 (r = -0.25) and higher preoperative pure-tone average (PTA) (r = -0.27) negatively correlated with CI2 outcomes.
- Predictive models for CI2 CNC scores were developed, incorporating these factors.
Conclusions:
- Preoperative hearing aid use and CI1 performance are key predictors of CI2 success.
- Factors like limited hearing loss duration and lower PTA in the second ear before CI2 also indicate better outcomes.
- Advanced age or long intervals between implantations do not necessarily predict poor CI2 results.
Related Concept Videos
Predicting Molecular Geometry
Prediction Intervals
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
End Point Prediction: Gran Plot
For potentiometric titration, the Gran plot is created by plotting...
Sensitivity, Specificity, and Predicted Value
Sensitivity is the...
Predicting Reaction Outcomes
Adult Stem Cells

