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Interleukin-18.

Shiying Wang1, Fang Chen1, Suxia Yang1

  • 1Department of Nephrology, Huaihe Hospital of Henan University.

International Heart Journal
|July 20, 2018
PubMed
Summary
This summary is machine-generated.

Interleukin-18 (IL-18) is a strong predictor of major adverse cardiovascular events (MACE) in hemodialysis patients. Higher IL-18 levels in these patients correlate with increased MACE risk, suggesting its utility as a biomarker.

Keywords:
Predictive value

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Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biomarker Research

Background:

  • Cardiovascular disease is a major complication in hemodialysis patients.
  • Inflammatory markers are implicated in cardiovascular risk in this population.

Purpose of the Study:

  • To evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACE) in hemodialysis patients.

Main Methods:

  • Prospective observational study with 45 hemodialysis patients and 40 healthy controls.
  • Measured IL-18 levels and assessed MACE as the primary endpoint.
  • Utilized multiple linear regression and ROC curve analysis.

Main Results:

  • Hemodialysis patients exhibited significantly higher IL-18 levels and MACE rates compared to controls (P < 0.01).
  • Serum creatinine and left ventricular ejection fraction influenced IL-18 levels.
  • IL-18 demonstrated strong predictive value for MACE with an AUC of 0.81 (P = 0.004).

Conclusions:

  • Elevated IL-18 levels are associated with a high incidence of MACE in hemodialysis patients.
  • IL-18 serves as a valuable predictive marker for MACE in this patient group.