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Updated: Feb 7, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Bullous Pemphigoid as an Adverse Reaction to Pembrolizumab: Two Case Reports
Kenneth Thomsen1, Jon Diernaes1, Trine Heide Øllegaard2
1Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Abstract:
Checkpoint inhibitors are novel and promising treatment options for different types of cancer. Programmed cell death 1 (PD-1) inhibitors, such as pembrolizumab, have been shown to significantly raise the survival rates of disseminated malignant melanoma (MM). Autoimmune adverse reactions are very common in checkpoint inhibitors. We present 2 cases of bullous pemphigoid, as adverse reactions to pembrolizumab-treated MM.
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