Prostatic Carcinogenesis: More Insights
Eman M Saied1, Hanan Alsaeid Alshenawy2
1Department of Pathology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
Journal of Microscopy and Ultrastructure
|July 20, 2018
Summary
Maspin and prohibitin (PHB) are overexpressed in prostate cancer, unlike in benign prostatic hyperplasia (BPH). Their increased levels correlate with higher Gleason scores, suggesting prognostic value in prostate cancer.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Prostate carcinoma is a leading cause of cancer death in men.
- Maspin and prohibitin (PHB) are implicated in various cancers, but their role in prostate carcinogenesis requires further investigation.
Purpose of the Study:
- To investigate the immunohistochemical expression of maspin and PHB in prostate carcinoma.
- To compare maspin and PHB expression in prostate carcinoma versus benign prostatic hyperplasia (BPH).
- To elucidate the roles of maspin and PHB in prostate carcinogenesis.
Main Methods:
- Histopathological examination of 30 prostate adenocarcinoma and 15 BPH tissue samples.
- Immunohistochemical evaluation of maspin and PHB expression in the studied tissues.
Main Results:
- Maspin expression was significantly higher in prostate carcinoma (88.9%) than in BPH (20%).
- PHB was exclusively detected in prostate carcinoma (84.4%), with no expression in BPH.
- Both maspin and PHB expression levels significantly increased with higher Gleason scores (P=0.0125 and P=0.0065).
Conclusions:
- Overexpression of maspin and PHB in prostate carcinoma highlights their involvement in carcinogenesis.
- Upregulation of maspin and PHB with increasing Gleason score suggests prognostic significance.
- PHB expression may serve as a biomarker to differentiate prostate carcinoma from BPH.
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