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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
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Core-Shell Nanoparticles as an Efficient, Sustained, and Triggered Drug-Delivery System.
Sonal Deshpande1, Sapna Sharma1, Veena Koul1,2
1Centre for Biomedical Engineering, Indian Institute of Technology-Delhi, Hauz Khas, New Delhi 110016, India.
ACS Omega
|July 20, 2018
Summary
This study developed novel radiofrequency-triggered gold core-polymeric shell nanoparticles for controlled doxorubicin release. A combination of two nanoparticle types enhanced cancer cell death, suggesting superior efficacy over single systems.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Controlling drug release from delivery vehicles is crucial for maximizing therapeutic effects.
- Multifunctional nanoparticles with multiple triggers are being developed for enhanced drug delivery.
- Radiofrequency (rf) offers excellent tissue penetration for triggering drug release in biological systems.
Purpose of the Study:
- To develop and evaluate a novel thermoresponsive gold core-polymeric shell nanoparticle system for triggered doxorubicin release.
- To investigate the efficacy of rf-triggered drug release using gold nanoparticles (AuNPs) and poly(N-isopropylacrylamide) (pNIPAm)-based shells.
- To compare the therapeutic effect of a combined nanoparticle system versus single nanoparticle systems.
Main Methods:
- Synthesized gold nanoparticles (AuNPs) with varying poly(N-isopropylacrylamide) (pNIPAm) and poly(N-isopropylmethacrylamide) (NIPMAm) shell compositions.
- Investigated rf-induced hyperthermia of AuNPs and temperature-dependent doxorubicin release from the polymeric shells.
- Evaluated nanoparticle biocompatibility, stability in biological media, and in vitro efficacy in HeLa cells upon rf exposure.
Main Results:
- The polymer coating did not impede the rf-heating efficiency of AuNPs.
- The nanoparticles demonstrated temperature-dependent doxorubicin release, exhibiting both burst and sustained release patterns.
- A mixture of two distinct polymeric shell nanoparticles induced significantly more HeLa cell death upon rf exposure compared to single nanoparticle systems.
- The developed nanoparticles were biocompatible and stable in biologically relevant media.
Conclusions:
- Thermoresponsive gold core-polymeric shell nanoparticles offer a promising platform for triggered and sustained doxorubicin delivery.
- Radiofrequency serves as an effective trigger for drug release due to its tissue penetration capabilities.
- Combined nanoparticle systems show enhanced therapeutic efficacy compared to single-component systems, paving the way for more effective cancer treatment strategies.
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