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Engineering Camptothecin-Derived Norbornene Polymers for Theranostic Application.

Saikat Mukherjee1, Himadri Dinda1, Ipsita Chakraborty1

  • 1Polymer Research Centre, Department of Chemical Sciences, Department of Physical Sciences, and Department of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, Nadia 741246, India.

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A novel nanotheranostic agent, Pnr-Cbt-Cpt-Pg-Bn, effectively delivers camptothecin and enables magnetic resonance imaging (MRI). This multifunctional system shows enhanced cellular uptake, highlighting its potential in personalized nanomedicine.

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Area of Science:

  • Nanomedicine
  • Polymer Chemistry
  • Biotechnology

Background:

  • Multifunctional nanotheranostic agents integrate diagnostics and therapeutics for personalized medicine.
  • Stimuli-responsive nanosystems offer advanced capabilities in drug delivery and monitoring.

Purpose of the Study:

  • To develop and evaluate a novel nanotheranostic agent, Pnr-Cbt-Cpt-Pg-Bn, for camptothecin delivery.
  • To incorporate magnetic resonance imaging (MRI) capability and enhance biocompatibility and site-specificity.

Main Methods:

  • Synthesis of a novel copolymer functionalized with a superparamagnetic norbornene cobalt unit and a poly(ethylene glycol)-biotin moiety.
  • Confirmation of MRI capability using NMR one-dimensional imaging.
  • In vitro evaluation of cellular uptake compared to free camptothecin.

Main Results:

  • The synthesized nanotheranostic agent, Pnr-Cbt-Cpt-Pg-Bn, demonstrated successful MRI capability.
  • The poly(ethylene glycol)-biotin modification enhanced biocompatibility and site-specificity.
  • In vitro studies showed significantly greater cellular uptake of the nanotheranostic agent compared to free camptothecin.

Conclusions:

  • The Pnr-Cbt-Cpt-Pg-Bn copolymer represents a promising nanotheranostic agent for effective camptothecin delivery.
  • This multifunctional nanoplatform exhibits enhanced potential for applications in personalized nanomedicine and cancer therapy.