Related Experiment Video
Updated: Feb 7, 2026

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
Published on: August 15, 2025
Preferential Mitochondrial Localization of a Goniothalamin Fluorescent Derivative
Ismael Raitz1, Roberto Y de Souza Filho2, Lorena P de Andrade2
1Institute of Chemistry, University of Campinas, Cidade Universitária Zeferino Vaz, 13083-970 Campinas, SP, Brazil.
Abstract:
A fluorescent 2,1,3-benzothiadiazole-containing goniothalamin derivative, BTD-GTN (1), has been synthesized and successfully tested in bioimaging experiments in live cells. The fluorescent compound proved to be capable of transposing the cell membranes, indicating its subcellular localization. The use of the benzothiadiazole core as the fluorophore revealed the favored localization of the GTN analogue 1 in the cytoplasm of live cells, preferentially in the mitochondria, in line with previous results that indicated the loss of mitochondrial transmembrane potential upon treatment with GTN. The results described herein highlight the potential of the BTD-GTN hybrid structures for future studies regarding the cellular mechanism of action of this family of compounds.
More Related Videos
Related Concept Videos
Animal Mitochondrial Genetics
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
Export of Mitochondrial and Chloroplast Genes
The Inner Mitochondrial Membrane
Mitochondrial Membranes
Local Attraction

