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Published on: July 29, 2011
Serum adiponectin in breast cancer: A meta-analysis
1Department of Obstetrics, West China Women's and Children's Hospital Key Laboratory of Birth and Related Diseases of Women and Children, Sichuan University Department of Cosmetic Plastic and Burns surgery, West China Hospital, Sichuan University, Chengdu International Education School, Southwest Medical University, Luzhou Department of Operations Management, West China Hospital, Sichuan University Department of West China Second University Hospital Quality improvement, West China Women's and Children's Hospital, Chengdu Dazhou vocational and technical college, Dazhou, PR China.
Background:
Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent.
Method:
A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size.
Results:
Finally, 31 eligible studies were included in this meta-analysis. The overall results indicated that serum adiponectin levels in BC cases were significantly lower than the controls (SMD = -0.33, P < 0.0001). As for the subgroup analysis of menstrual status, serum adiponectin levels were significantly lower in pre- and postmenopausal BC cases. Moreover, the subgroup analysis by ethnicity in pre- and postmenopausal group indicated an inverse association between adiponectin levels and BC risk in Asian population, but not in Caucasian population.
Conclusion:
The present meta-analysis suggests that low serum adiponectin concentration may be associated with an increased BC risk in premenopausal and postmenopausal women, especially among Asians. Adiponectin may serve as a biomarker of BC risk and help to identify subjects at high risk for BC development.
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