Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Master Transcription Regulators02:23

Master Transcription Regulators

2.8K
2.8K
Chemical Formulas02:52

Chemical Formulas

61.4K
A chemical formula presents information about the proportions of atoms constituting a particular chemical compound or molecule, mainly using symbols of elements and numbers. At times other symbols, such as dashes, parentheses, brackets, commas, plus, and minus signs, are also used. A chemical formula can be one of three types – molecular, empirical, and structural.
61.4K
Chemical Equations03:10

Chemical Equations

81.8K
Chemical equations represent the identities and relative quantities of substances involved in a chemical reaction. The substances undergoing reaction are called reactants, and their formulas are placed on the left side of the equation. The substances generated by the reaction are called products, and their formulas are placed on the right side of the equation. Plus signs (+) separate individual reactant and product formulas, and an arrow (→) separates the reactant and product (left and right)...
81.8K
Chemical Reactions01:19

Chemical Reactions

95.9K
A chemical reaction is a process by which the bonds in the atoms of substances are rearranged to generate new substances. Matter cannot be created or destroyed in a chemical reaction—the same type and number of atoms that make up the reactants are still present in the products. Merely, the rearrangement of chemical bonds produces new compounds.
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them...
95.9K
Types of Chemical Bonds02:37

Types of Chemical Bonds

94.4K
Chemical bonding theories were pioneered by American chemist Gilbert N. Lewis. He developed a model called the Lewis model to explain the type and formation of different bonds. Chemical bonding is central to chemistry; it explains how atoms or ions bond together to form molecules. It explains why some bonds are strong and others are weak, or why one carbon bonds with two oxygens and not three; why water is H2O and not H4O. 
94.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An improved synthesis of Compound 11, a unique bicyclic melanocortin-3 antagonist.

Peptide science (Hoboken, N.J.)·2025
Same author

Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice.

The Journal of clinical investigation·2024
Same author

A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts the Coactivator Med25 Protein-Protein Interactions.

Angewandte Chemie (International ed. in English)·2024
Same author

Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents.

bioRxiv : the preprint server for biology·2023
Same author

Inhibition of CREB Binding and Function with a Dual-Targeting Ligand.

Biochemistry·2023
Same author

C-H radiocyanation of bioactive molecules <i>via</i> sequential iodination/copper-mediated cross-coupling.

Chemical science·2023

Related Experiment Video

Updated: Feb 7, 2026

Mistletoe Eradicator - A Novel Tool for Simultaneous Mechanical and Chemical Control of Mistletoe
06:16

Mistletoe Eradicator - A Novel Tool for Simultaneous Mechanical and Chemical Control of Mistletoe

Published on: March 1, 2022

4.6K

Modulating the masters: chemical tools to dissect CBP and p300 function.

Meghan E Breen1, Anna K Mapp1

  • 1Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

Current Opinion in Chemical Biology
|July 20, 2018
PubMed
Summary

Researchers are developing targeted therapies for diseases by focusing on transcription regulators like CREB binding protein (CBP) and p300. New chemical probes show promise for understanding these master coactivators and their roles in disease.

More Related Videos

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

10.0K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K

Related Experiment Videos

Last Updated: Feb 7, 2026

Mistletoe Eradicator - A Novel Tool for Simultaneous Mechanical and Chemical Control of Mistletoe
06:16

Mistletoe Eradicator - A Novel Tool for Simultaneous Mechanical and Chemical Control of Mistletoe

Published on: March 1, 2022

4.6K
High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

10.0K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Discovery

Background:

  • Transcription dysregulation is implicated in numerous human diseases.
  • CREB binding protein (CBP) and its paralogue p300 are key transcriptional coactivators.
  • Targeting CBP/p300 offers a therapeutic strategy for various diseases.

Purpose of the Study:

  • To review the development of selective chemical tools targeting CBP/p300 domains.
  • To highlight the utility of these chemical probes in understanding CBP/p300 function.
  • To explore interdomain interactions and differential coactivator usage.

Main Methods:

  • Review of recent literature on chemical probe development for CBP/p300.
  • Analysis of studies utilizing selective CBP/p300 inhibitors.
  • Examination of research on CBP/p300 interdomain communication.

Main Results:

  • Several chemical tools targeting CBP/p300 domains with acceptable selectivity have been developed.
  • These probes serve as valuable chemical probes for biological research.
  • Recent studies have leveraged these probes to elucidate CBP/p300 biology.

Conclusions:

  • Selective chemical probes for CBP/p300 are advancing research into transcription regulation.
  • These tools facilitate a deeper understanding of disease mechanisms driven by transcription dysregulation.
  • Further development and application of these probes hold therapeutic potential.