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Differentiation measures for conservation genetics.

Lou Jost1, Frederick Archer2, Sarah Flanagan3

  • 1Fundacion EcoMinga Baños Ecuador.

Evolutionary Applications
|July 21, 2018
PubMed
Summary
This summary is machine-generated.

Fixation measures like FST quantify genetic nearness to fixation, while allelic differentiation measures like Jost's D assess genetic diversity between populations. Misinterpreting fixation measures for conservation can be misleading.

Keywords:
fixation indicesgenetic differentiation indicesgenetic diversity

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Area of Science:

  • Population genetics
  • Conservation genetics
  • Evolutionary biology

Background:

  • Two main classes of population structure measures exist: fixation measures (e.g., FST) and allelic differentiation measures (e.g., Jost's D).
  • These measures quantify distinct, complementary aspects of population structure.
  • Fixation measures are often misapplied in conservation contexts.

Purpose of the Study:

  • To compare fixation measures and allelic differentiation measures.
  • To clarify their distinct roles in population genetics and conservation.
  • To correct misinterpretations of fixation measures in conservation applications.

Main Methods:

  • Theoretical comparison of fixation and allelic differentiation measures.
  • Analysis of the finite island model to illustrate measure behavior.
  • Examination of empirical aspects relevant to conservation.

Main Results:

  • Fixation measures indicate nearness to genetic fixation, while allelic differentiation measures quantify relative genetic diversity between demes.
  • The absolute number of migrants influences nearness to fixation, not allelic differentiation, in low mutation rate models.
  • Jost's D and related factors predict genetic divergence at equilibrium.

Conclusions:

  • Allelic differentiation measures are crucial for conservation decisions requiring assessment of genetic composition differences between demes.
  • Fixation measures should not be used as proxies for allelic differentiation in conservation.
  • Direct measurement of allelic differentiation at relevant loci is recommended for accurate conservation assessments.