Related Experiment Video
Updated: Feb 7, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics
Joshua Z Goldenberg1,2, Dominik Mertz3, Bradley C Johnston4
1Bastyr University Research Institute, Kenmore, Washington.
Clinical Question:
In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events?
Bottom Line:
Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low-quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.
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