Mycophenolate mofetil sensor based on molecularly imprinted polymer/multi-walled carbon nanotubes modified carbon...

Area of Science:

• Electroanalytical Chemistry
• Materials Science
• Biomedical Engineering

Background:

• Mycophenolate mofetil (MMF) is an important immunosuppressant drug.
• Accurate monitoring of MMF levels is crucial for therapeutic efficacy and patient safety.
• Development of selective and sensitive detection methods for MMF is needed.

Purpose of the Study:

• To develop a novel electrochemical sensor for the selective and sensitive detection of mycophenolate mofetil (MMF).
• To utilize molecularly imprinted polymer (MIP) combined with multi-walled carbon nanotubes (MWCNTs) for enhanced MMF recognition.
• To evaluate the sensor's performance in biological fluid samples.

Main Methods:

• Fabrication of a carbon paste electrode modified with MIP and MWCNTs.
• Electrochemical characterization using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS).
• Square wave voltammetry (SWV) for MMF quantification after parameter optimization.

Main Results:

• The MIP-based sensor demonstrated high selectivity and sensitivity for MMF detection.
• A linear dynamic range for MMF was observed from 9.9 nM to 87 μM.
• The sensor achieved a low detection limit of 7.0 nM.
• The sensor exhibited excellent selectivity, sensitivity, and stability in biological fluid analysis.

Conclusions:

• The developed MIP-modified electrode is a promising candidate for accurate and reliable MMF monitoring.
• The combination of MIP and MWCNTs significantly enhances sensor performance.
• The sensor's practical applicability in biological samples validates its potential for clinical use.