Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chemistry of Carbohydrates

Chemistry of Carbohydrates

Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...

Chemistry of Carbohydrates

Chemistry of Carbohydrates

What is Organic Chemistry?

What is Organic Chemistry?

Organic chemistry is the study of compounds of carbon called organic compounds. Organic compounds either originate from living organisms or are synthesized by chemists. A defining trait of these compounds is the presence of carbon as the principal element, which is bonded to other carbon atoms and other elements such as hydrogen, oxygen, nitrogen, and sulfur. The existence of a wide array of organic molecules is a consequence of carbon atoms’ ability to form up to four strong bonds to...

Chemistry of the Cell

Chemistry of the Cell

The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...

Chemistry of the Cell

Chemistry of the Cell

EDTA: Chemistry and Properties

EDTA: Chemistry and Properties

Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome.

Nature communications·2026

Same author

Blue carbon inventories of Spain and Portugal for their inclusion in national climate mitigation strategies.

Marine pollution bulletin·2026

Same author

Redirecting linear hydrocarbon metabolism toward polyhydroxyalkanoate biosynthesis.

Microbial cell factories·2026

Same author

PFAS Contamination in Europe: Generating Knowledge and Mapping Known and Likely Contamination with "Expert-Reviewed" Journalism.

Environmental science & technology·2024

Same author

Neural network enhanced aging time measurements of diary product remaining with infrared spectroscopy.

Heliyon·2023

Same author

Application of CO<sub>2</sub> Gas Hydrates as Leavening Agents in Black-and-White Cookies.

Foods (Basel, Switzerland)·2023

Search research articles

Related Experiment Video

Updated: Feb 7, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Published on: July 20, 2016

Click chemistry in sphingolipid research.

Eduardo Izquierdo¹, Antonio Delgado¹

¹Spanish National Research Council (CSIC), Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biomedicinal Chemistry, Research Unit on Bioactive Molecules (RUBAM), Jordi Girona 18-26, 08034 Barcelona, Spain; University of Barcelona (UB), Faculty of Pharmacy and Food Sciences, Department of Pharmacology, Toxicology and Medicinal Chemistry, Unit of Pharmaceutical Chemistry (Associated Unit to CSIC), Avda. Joan XXIII 27-31, 08028 Barcelona, Spain.

Chemistry and Physics of Lipids

|July 21, 2018

Summary

Click chemistry offers powerful tools for chemical biology, enabling diverse molecular interactions. This review highlights new click chemistry strategies for studying sphingolipid metabolism and function.

More Related Videos

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Related Experiment Videos

Last Updated: Feb 7, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Published on: July 20, 2016

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Area of Science:

Chemical Biology
Organic Chemistry
Biochemistry

Background:

Click chemistry, coined in 2001, describes highly efficient and versatile reactions.
It has significantly advanced drug discovery and bioorthogonal chemistry.
Applications are widespread, yet limited in sphingolipid research.

Purpose of the Study:

To review recent click chemistry applications in sphingolipid research.
To highlight novel sphingolipid probes and analogues.
To showcase the utility of click chemistry in understanding sphingolipid metabolism.

Main Methods:

Review of recent literature on click chemistry in chemical biology.
Focus on sphingolipid probes and analogues.
Emphasis on the [3+2] azide-alkyne cycloaddition.

Main Results:

Identification of new click chemistry strategies for sphingolipid studies.
Development of functionalized sphingolipid probes for in situ reactions.
Design of novel sphingolipid analogues driven by click chemistry principles.

Conclusions:

Click chemistry is expanding its reach into sphingolipid research.
New tools enable deeper investigation of sphingolipid functions and metabolism.
This review provides a concise overview of recent advancements.