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Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT.

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Pulsatile trabecular meshwork (TM) motion differs between internal and external regions and changes with accommodation. Phase-sensitive OCT (PhS-OCT) can reliably measure these TM dynamics, aiding glaucoma research.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Physiology

Background:

  • The trabecular meshwork (TM) plays a crucial role in regulating intraocular pressure (IOP).
  • Understanding TM's biomechanical properties, including its pulsatile motion, is vital for diagnosing and managing glaucoma.
  • Current imaging techniques have limitations in characterizing dynamic TM behavior.

Purpose of the Study:

  • To characterize the pulsatile motion of the trabecular meshwork (TM) in healthy individuals.
  • To investigate how TM motion changes during accommodation using phase-sensitive optical coherence tomography (PhS-OCT).
  • To establish the reproducibility of PhS-OCT measurements for TM pulsatile motion.

Main Methods:

  • A novel PhS-OCT prototype was developed to measure pulsatile TM motion.
  • 13 healthy subjects were imaged, with measurements taken under both refractive correction and 3.0 diopters of accommodation.
  • Maximum velocity (MV) and cumulative displacement (CD) were quantified in the internal (IMV, ICD) and external (EMV, ECD) regions of the TM.

Main Results:

  • PhS-OCT demonstrated high reproducibility for TM motion parameters (ICC > 0.75).
  • The external TM region exhibited significantly higher motion (EMV, ECD) compared to the internal region (IMV, ICD) in normal subjects (P < 0.0001).
  • Accommodation significantly increased TM pulsatile motion (MV and CD) in both regions (P < 0.023), with the external region remaining more dynamic.

Conclusions:

  • This study highlights distinct regional differences in TM pulsatile motion and its modulation by accommodation.
  • PhS-OCT is a valuable tool for assessing TM biomechanics and function.
  • These findings provide insights into TM's role in IOP regulation and suggest potential applications for PhS-OCT in glaucoma management.