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Measuring Outflow Facility And Ocular Compliance In Ex Vivo Mouse Eyes Using A Syringe-pump System.

Cong Li¹, Yuteng Li², Pengchao Feng¹

¹Department of Pharmacology, School of Pharmacy, Qingdao University.

Journal of Visualized Experiments : Jove

|June 22, 2026

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A low-cost syringe-pump system was optimized to better evaluate trabecular meshwork (TM) and Schlemm's canal (SC) function in maintaining intraocular pressure (IOP). This improved system accurately measures outflow facility (C) and ocular compliance (ϕ).

Area of Science:

Ophthalmology
Biomedical Engineering
Ocular Biomechanics

Background:

Intraocular pressure (IOP) regulation is vital for ocular health, involving the trabecular meshwork (TM), Schlemm's canal (SC), and corneoscleral shell.
Outflow facility (C) and ocular compliance (ϕ) are key biomechanical parameters reflecting aqueous humor drainage and ocular elasticity, respectively.
Previous analysis of TM and SC function using simple methods had limitations.

Purpose of the Study:

To optimize a cost-effective syringe-pump system for evaluating TM and SC biomechanical properties.
To enhance the analytical methods for assessing outflow facility (C) and ocular compliance (ϕ).

Main Methods:

Optimized a syringe-pump system using analytical approaches from established pressure-controlled ocular perfusion systems.

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Applied these optimized methods to measure C and ϕ in ex vivo eyes.

Main Results:

The optimized syringe-pump system provided consistent measurements of C and ϕ.
Ex vivo measured values for C and ϕ were comparable to those reported in the literature using perfusion systems.

Conclusions:

The refined, low-cost syringe-pump system effectively evaluates the biomechanical properties of the TM and SC.
This system offers a straightforward and accessible method for assessing key parameters in IOP homeostasis.