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Gut-derived serotonin contributes to bone deficits in colitis

B Lavoie1, J A Roberts1, M M Haag1

  • 1Department of Neurological Sciences, The University of Vermont, Burlington, VT, USA.

Pharmacological Research
|July 22, 2018
PubMed
Summary

Serotonin (5-HT) contributes to bone loss in inflammatory bowel disease (IBD) models. Inhibiting serotonin synthesis or blocking its receptors significantly reduced bone loss in colitis, suggesting 5-HT plays a key role.

Keywords:
5-HT(1B) receptorDSS-induced colitisPeripheral 5-HTbone loss

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