Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Responses to Gravity and Touch

Responses to Gravity and Touch

Gravitropism: Plant Responses to Gravity

Humoral Immune Responses

Humoral Immune Responses

Responses to Drought and Flooding

Responses to Drought and Flooding

Water plays a significant role in the life cycle of plants. However, insufficient or excess of water can be detrimental and pose a serious threat to plants.

Responses to Salt Stress

Responses to Salt Stress

Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibition.

Science advances·2026

Same author

A model of transcriptional bursting dynamics based on coupling between chromatin and enhancer states.

bioRxiv : the preprint server for biology·2025

Same author

HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion.

Cell·2025

Same author

Neuralized-like proteins differentially activate Notch ligands.

EMBO reports·2025

Same author

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.

Development (Cambridge, England)·2025

Same author

Fat4 intracellular domain controls internalization of Fat4/Dchs1 planar polarity membrane complexes.

Biophysical journal·2025

Search research articles

Related Experiment Video

Updated: Feb 7, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Modeling the Notch Response.

Udi Binshtok¹, David Sprinzak²

¹Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel.

Advances in Experimental Medicine and Biology

|July 22, 2018

Summary

This summary is machine-generated.

Mathematical modeling of NOTCH signaling provides quantitative insights into developmental processes like lateral inhibition and somitogenesis. These computational approaches help predict complex behaviors and guide future experiments in cell differentiation.

Keywords:

Boundary formation Cell division Cell morphology Cis-inhibition Filopodia Lateral inhibition Mathematical modeling NOTCH signaling Pattern formation

More Related Videos

Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure

Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure

Published on: April 25, 2025

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Related Experiment Videos

Last Updated: Feb 7, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure

Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure

Published on: April 25, 2025

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Area of Science:

Developmental Biology
Computational Biology
Systems Biology

Background:

NOTCH signaling is a fundamental pathway regulating cell differentiation across the animal kingdom.
Understanding NOTCH-mediated patterning requires advanced quantitative methodologies.
Theoretical and computational approaches are increasingly vital for studying NOTCH signaling.

Purpose of the Study:

To review recent advances in mathematical modeling of NOTCH-mediated patterning.
To highlight new modeling approaches incorporating complex biological features.
To provide a comprehensive overview of computational strategies for analyzing NOTCH response.

Main Methods:

Review of recent theoretical and computational studies on NOTCH signaling.
Discussion of mathematical models for lateral inhibition, including cis-interactions and cellular protrusions.
Analysis of models for somitogenesis, cell morphology effects, and boundary formation.

Main Results:

Mathematical models offer insights into complex and counterintuitive NOTCH pathway behaviors.
New models incorporate factors like cis-interactions, cell protrusions, division, and external signals.
Computational approaches are being developed to understand somitogenesis, cell morphology, and boundary formation in NOTCH signaling.

Conclusions:

Modeling is crucial for a deeper understanding of NOTCH signaling and its role in development.
Computational methods provide predictive power to guide experimental research.
The field is advancing with models that integrate diverse biological complexities of the NOTCH pathway.