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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.7K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.7K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K

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Related Experiment Video

Updated: Feb 7, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

8.2K

Notch and Neurogenesis.

Anna Engler1, Runrui Zhang1, Verdon Taylor2

  • 1Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.

Advances in Experimental Medicine and Biology
|July 22, 2018
PubMed
Summary
This summary is machine-generated.

Neural stem cells (NSCs) generate neurons throughout life. Notch signaling regulates NSC activity and fate, influencing brain regeneration and heterogeneity in adult neural stem cells.

Keywords:
Central nervous systemDentate gyrusDevelopmentHesMaintenanceNeural stem cellsNeurogenesisNotchRbpjSubventricular zone

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Related Experiment Videos

Last Updated: Feb 7, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Neurogenesis Using P19 Embryonal Carcinoma Cells
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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Neurogenesis, the formation of neurons, is crucial for brain development and continues throughout adult life.
  • Neural stem cells (NSCs) drive both embryonic and adult neurogenesis but are regulated by their niche environment.
  • Understanding NSC regulation is key to comprehending brain development and regeneration.

Purpose of the Study:

  • To discuss the role of Notch signaling in controlling neurogenesis and regeneration in embryonic and adult vertebrates.
  • To explore how differences in Notch signaling contribute to the heterogeneity observed among adult neural stem cell populations.
  • To highlight the importance of understanding diverse NSC populations for effective brain regeneration strategies.

Main Methods:

  • Review of existing literature on Notch signaling pathways in neurogenesis.
  • Analysis of studies investigating neural stem cell behavior in embryonic and adult brains.
  • Discussion of the implications of Notch signaling for neural stem cell heterogeneity and brain repair.

Main Results:

  • Notch signaling is a common regulatory mechanism across various neural stem cell populations.
  • Variations in Notch signaling pathways likely underlie the functional diversity observed in adult neural stem cells.
  • The local niche significantly influences neural stem cell activity and differentiation.

Conclusions:

  • Notch signaling plays a pivotal role in regulating neurogenesis and brain regeneration.
  • Understanding the heterogeneity of neural stem cells, influenced by Notch signaling, is critical for advancing regenerative medicine.
  • Targeting Notch pathways may offer therapeutic potential for brain repair.