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Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
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Structure tensor informed fibre tractography at 3T.

Kwok-Shing Chan1, David G Norris1,2,3, José P Marques1

  • 1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.

Human Brain Mapping
|July 22, 2018
PubMed
Summary
This summary is machine-generated.

Structure tensor informed fibre tractography (STIFT) using 3T data improved optic radiation delineation. This advanced method may reduce false-positive connections in brain connectivity analysis.

Keywords:
diffusion weighted imagingoptic radiation, quantitative susceptibility mappingstructural connectivitytractography

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Area of Science:

  • Neuroimaging
  • Diffusion MRI
  • Quantitative Susceptibility Mapping

Background:

  • Structure tensor informed fibre tractography (STIFT) previously utilized multi-field strength data.
  • Limitations in applicability arise from combining data from different magnetic field strengths.

Purpose of the Study:

  • To implement STIFT using only 3T data, combining diffusion-weighted imaging (DWI) and gradient-recalled echo (GRE) images.
  • To explore the utility of T2* maps and quantitative susceptibility maps (QSM) derived from complex-valued GRE data for improved fibre delineation.

Main Methods:

  • STIFT was implemented using DWI and GRE images acquired at 3T.
  • T2* maps and QSM derived from complex GRE data were utilized instead of magnitude GRE data.
  • Single-seed tractography and whole-brain connectivity analysis were performed.

Main Results:

  • STIFT with 3T data improved the delineation of the optic radiation from adjacent white matter tracts compared to standard DWI tractography.
  • No systematic differences in connectivity were observed between STIFT and DWI tractography in atlas-based analysis.
  • A reduction in statistically significant connections was noted with STIFT, suggesting a potential decrease in false positives.

Conclusions:

  • STIFT implemented with 3T data, including T2* and QSM, enhances fibre tract delineation.
  • While local tractography improvements were observed, they did not systematically alter atlas-based connectivity measures.
  • STIFT shows promise in reducing false-positive connections in structural connectivity analyses.