Physical plasma and leukocytes - immune or reactive?

Area of Science:

• Immunology
• Plasma Medicine
• Biophysics

Background:

• Leukocytes are critical immune cells involved in recognizing and eliminating pathogens.
• Physical plasmas have emerged as a therapeutic tool in medicine, particularly for dermatological and oncological applications.
• Plasma treatments can directly or indirectly influence leukocytes present in treated tissues.

Purpose of the Study:

• To review the effects of plasma treatment on innate and adaptive immune cells (leukocytes).
• To contextualize these effects within the fields of wound healing and oncology.
• To highlight the importance of studying leukocyte responses to plasma treatment in vitro and in vivo.

Main Methods:

• Literature review of studies investigating plasma-immune cell interactions.
• Synthesis of findings on direct and indirect effects of plasma on leukocytes.
• Integration of data within the frameworks of wound healing and cancer therapy.

Main Results:

• Plasma treatments modulate leukocyte behavior and function.
• These modulations have implications for immune responses in wound healing and cancer.
• Both in vitro and in vivo studies demonstrate significant leukocyte alterations post-plasma exposure.

Conclusions:

• Understanding plasma-leukocyte interactions is crucial for optimizing plasma medicine.
• Plasma therapy holds potential in modulating immune responses for therapeutic benefit in wound healing and oncology.
• Further research is needed to fully elucidate the mechanisms and therapeutic applications.