Selective Palladium-Catalyzed Carbonylation of Alkynes: An Atom-Economic Synthesis of 1,4-Dicarboxylic Acid Diesters
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Updated: Feb 7, 2026
Synthesis Method for Cellulose Nanofiber Biotemplated Palladium Composite Aerogels
Published on: May 9, 2019
Jiawang Liu1, Kaiwu Dong1, Robert Franke2,3
1Leibniz-Institut für Katalyse e.V. an der Universität Rostock , Albert-Einstein-Str. 29a , Rostock , 18059 , Germany.
Abstract:
A class of novel diphosphine ligands bearing pyridine substituents was designed and synthesized for the first time. The resulting palladium complexes of L1 allow for chemo- and regioselective dialkoxycarbonylation of various aromatic and aliphatic alkynes affording a wide range of 1,4-dicarboxylic acid diesters in high yields and selectivities. Kinetic studies suggest the generation of 1,4-dicarboxylic acid diesters via cascade hydroesterification of the corresponding alkynes. Based on these investigations, the chemo- and regioselectivities of alkyne carbonylations can be controlled as shown by switching the ligand from L1 to L3 or L9 to give α,β-unsaturated esters.
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