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Microbes and Alzheimer's Disease: New Findings Call for a Paradigm Change
Jürgen G Haas1, Richard Lathe1
1Division of Infection and Pathway Medicine, University of Edinburgh, Little France Crescent, Edinburgh, UK.
Trends in Neurosciences
|July 24, 2018
Abstract:
Two papers in Neuron provide compelling new indications of a link between herpesviruses and Alzheimer's disease (AD). Readhead et al. report an increased abundance of human herpesviruses 6A and 7 (HHV-6A/7) in AD brain, whereas Eimer et al. show that binding of the AD signature protein, Aβ, to herpes simplex virus type 1 (HSV-1) and HHV-6 surface glycoproteins causes fibrillar Aβ agglutination that can protect against viral challenge.