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Interfacing Complex Laboratory Instruments during a Change to Epic Beaker.

Gregory David Scott1, Cary Schrandt2, Chandler C Ho2

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

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|July 24, 2018
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Summary
This summary is machine-generated.

Custom interfaces integrating laboratory instruments like LC-MS/MS with LIS systems significantly reduce errors and save technician time. This study details a successful interface for 25-OH Vitamin D and testosterone testing, improving efficiency.

Keywords:
BeakerData Innovationsinterfacemiddleware

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Area of Science:

  • Clinical Chemistry
  • Laboratory Informatics
  • Mass Spectrometry

Background:

  • Laboratory information systems (LIS) require custom interfaces for unconventional devices to minimize transcription errors and improve turnaround times.
  • Complex, high-volume tests like 25-OH Vitamin D using liquid chromatography-tandem mass spectrometry (LC-MS/MS) necessitate custom interfaces when vendor or LIS-supplied options are unavailable.
  • This work details the interfacing of an API 5000 LC-MS/MS instrument with the Epic Beaker LIS using in-house scripting and Data Innovations middleware.

Purpose of the Study:

  • To describe the development and implementation of a custom interface between an LC-MS/MS instrument and a new LIS.
  • To reduce transcription errors and improve turnaround time for high-volume laboratory tests.
  • To demonstrate a flexible and durable interface solution for laboratory instrumentation.

Main Methods:

  • Developed custom scripting software for input interfacing, converting Epic-generated order lists into a format compatible with the instrument software (Analyst®).
  • Utilized a unidirectional instrument driver from Data Innovations for output interfacing, transferring selected data from the LC-MS/MS system to the LIS.
  • Created and validated a new driver through Data Innovations, a process that took approximately six months.

Main Results:

  • The custom interface was successfully implemented for 25-OH Vitamin D and testosterone testing, accommodating significant increases in test volume.
  • Reporting time for 25-OH Vitamin D results decreased by 82%, saving 1370 technician hours.
  • Reporting time for testosterone results decreased by 75%, saving 400 technician hours.

Conclusions:

  • A hybrid approach combining custom scripting with commercial middleware provides a robust and adaptable interface solution for laboratory instruments like LC-MS/MS.
  • This interface strategy is flexible and can accommodate future updates to instrument software, networking protocols, and LIS functionalities.
  • The implemented solution demonstrates significant efficiency gains and cost savings in high-volume laboratory testing environments.