Related Experiment Video

Updated: Feb 7, 2026

Evaluating the Impact of Hydraulic Fracturing on Streams using Microbial Molecular Signatures
09:11

Evaluating the Impact of Hydraulic Fracturing on Streams using Microbial Molecular Signatures

Published on: April 4, 2021

3.5K

Molecular pathogenesis of fracture nonunion

Zi-Chuan Ding1, Yi-Kai Lin1, Yao-Kai Gan1

  • 1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 200011, 639 Zhizaoju Road, Shanghai, China.

Journal of Orthopaedic Translation
|July 24, 2018
PubMed

Insights

Understanding fracture nonunion molecular pathogenesis is key. This review summarizes genetic factors, cytokines, nitric oxide, and Wnt signaling, offering insights into prevention and treatment strategies for this complex bone healing complication.

Area of Science:

  • Orthopedics
  • Molecular Biology
  • Biochemistry

Background:

  • Fracture nonunion is a significant clinical challenge with unclear molecular pathogenesis.
  • Understanding the molecular basis of nonunion is crucial for developing effective prevention, diagnosis, and treatment strategies.

Purpose of the Study:

  • To review and summarize current knowledge on the molecular pathogenesis of fracture nonunion.
  • To highlight the roles of genetic factors, cytokines, and signaling pathways in nonunion development.

Main Methods:

  • Literature review of studies on fracture nonunion pathogenesis.
  • Analysis of evidence from in vitro, animal, and human studies.
  • Synthesis of findings on genetic factors, cytokines, and signaling pathways.

Main Results:

  • Fracture nonunion development is linked to genetic factors.
  • Key cytokines (TNF-α, IL-6, BMPs, IGFs, MMPs, VEGF) and pathways (nitric oxide, Wnt) are implicated.
  • Evidence supports the role of these molecular factors in nonunion across different study models.

Conclusions:

  • Molecular pathogenesis of fracture nonunion involves genetic predisposition and dysregulated cytokine signaling.
  • Further investigation into the interplay between genetic alterations and cytokine expression is warranted.
  • This understanding can guide the development of novel therapeutic strategies for fracture nonunion.
Keywords:
CytokineGeneMolecular pathogenesisNonunion

More Related Videos

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents06:59

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents

Published on: August 14, 2018

14.1K
Transverse Fracture of the Mouse Femur with Stabilizing Pin03:57

Transverse Fracture of the Mouse Femur with Stabilizing Pin

Published on: December 29, 2021

4.1K

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
662
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
888
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.5K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K
Molecular Models02:00

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.8K